New research from 23andMe has identified specific genetic variants that increase the risk of long COVID, a condition affecting many COVID-19 survivors. The study, involving over 174,000 participants from diverse ethnic backgrounds, revealed three genetic loci associated with heightened risk: HLA-DQA1-HLA-DQB1, ABO, and BPTF-KPAN2-C17orf58. It also highlighted the role of chronic conditions like depression and fibromyalgia in exacerbating this risk.
Long COVID is characterized by persistent symptoms such as fatigue and cognitive impairment, impacting an estimated 10-80% of those who recover from COVID-19. The research indicates that individuals with preexisting conditions, including high blood pressure and autoimmune disorders, are more likely to develop long COVID.
The study utilized extensive genotype data and Mendelian randomization models to explore genetic predispositions and their effects on long COVID risk. Notably, the findings suggest that chronic fatigue, fibromyalgia, and depression significantly contribute to the likelihood of developing long COVID.
This comprehensive analysis not only sheds light on the genetic factors involved but may also inform future therapeutic strategies for managing long COVID and related conditions.