The Wellcome Sanger Institute, University of Cambridge, and the Institute of Biomedicine of Valencia have conducted a detailed study on Staphylococcus aureus, a bacterium that commonly inhabits the human body. This research aims to enhance the understanding of its adaptation mechanisms, potentially improving infection prevention, diagnosis, and treatment.
By analyzing the genomes of thousands of S. aureus isolates from human noses and skin, researchers identified crucial genes that facilitate bacterial adaptation and persistence. A novel genomic analysis approach revealed mutations that help certain strains evade the human immune system and develop antibiotic resistance.
Dr. Ewan Harrison from the Wellcome Sanger Institute stated, "While Staphylococcus aureus bacteria are harmless to many people, for others they can cause potentially life-threatening infections. Our study gives a detailed new understanding of how these bacteria adapt and evolve in order to survive on and in their human carriers at a genetic level."
Dr. Francesc Coll from the Institute of Biomedicine of Valencia added, "Understanding how bacteria respond to antibiotic treatments has made it possible to identify the genetic changes that allow them to survive the attack of antibiotics. These mutations can be used as diagnostic markers, as well as to design new therapeutic strategies and a more rational and effective use of antibiotics."
This study emphasizes the importance of further investigation into the pathways uncovered, which could lead to advancements in tackling infections caused by these bacteria.