Genetic Link Between Canine and Human Obesity Unveiled: DENND1B Gene Identified

Researchers at the University of Cambridge have identified genetic variants linked to obesity in British Labrador retrievers, with relevance to human obesity. The study highlights the DENND1B gene, associated with approximately 8% more body fat in dogs carrying the variant. This gene regulates energy balance through the leptin melanocortin pathway, influencing appetite and energy expenditure. Alyce McClellan cautioned against viewing these genes as direct targets for weight-loss medications due to their broader biological implications. The study also found that dogs with a higher genetic risk for obesity showed a greater interest in food and were less selective eaters, mirroring findings in humans. Consistent diet and exercise management effectively mitigated obesity risks in genetically predisposed dogs. Dr. Eleanor Raffan emphasized that genetic predispositions to weight management challenges are not moral failings. The study involved assessing body fat and eating behaviors in Labradors, with genetic analysis pinpointing genes associated with increased body fat. Veterinarians and researchers suggest using puzzle feeders and spreading out food portions to manage canine obesity. The research reinforces the shared genetic challenges of obesity in dogs and humans, potentially leading to new insights for prevention and treatment.