Obesity Genes Shared Between Dogs and Humans Identified by Cambridge University Study

A Cambridge University study has identified genes linked to obesity in both dogs and humans. Researchers analyzed the genomic map and health status of 241 Labrador Retrievers, revealing that canine obesity genes are associated with rare and common forms of obesity in humans. The study found that dogs with a variant of the DENND1B gene had approximately 8% more body fat. Four other genes, also present in both species, play a less significant but contributing role in weight gain. These genes are complex targets for potential weight-loss drugs. Researchers also addressed the "atavistic hunger" of Labradors, emphasizing the importance of diet management. Dogs at higher risk of obesity exhibit increased appetite, mirroring the human condition. Strict diet control and exercise are crucial to prevent obesity, especially in individuals with unfavorable genetic variants. The study highlights the influence of DENND1B on the brain's satiety regulation pathway, specifically the leptin-melanocortin pathway, a key target for anti-obesity drugs. Understanding this biology may improve obesity treatment. The research also quantified the genetic risk of obesity in individual dogs, emphasizing the need for owners to manage their pets' diet and exercise.