Scientists worldwide are making strides in the quest for an "elixir of youth," aiming to enhance both lifespan and quality of life by preserving physical and mental health.
Researchers from the Weizmann Institute of Science report that they are nearing the discovery of a vaccine against aging that could prevent age-related cognitive decline.
This "anti-aging" vaccine, which may combat dementia and other aging effects, is no longer a concept of science fiction, according to the researchers. Their new approach targets the immune system to reduce the "internal enemies" that contribute to cognitive decline and the aging process.
In their publication in the electronic scientific journal Neuron, the researchers explain that as people age, the immune system weakens, leading to increased inflammation and the accumulation of "zombie cells" in the body. These cells no longer function properly and remain in body tissues instead of being cleared away.
The brain is particularly vulnerable to this "immunological aging," as the deterioration of the immune system can lead to damage associated with dementia. The researchers have sought a specific type of protein in the brain that could trigger an immune response, using it as a "vaccine against aging."
Additionally, the use of gerolytics—drugs that target "zombie cells"—is considered promising in combating aging.
Cognitive decline, which refers to memory and thinking problems, can be an early sign of dementia, though this is not always the case. Memory and concentration issues increase with age but do not always indicate cognitive decline. However, when these symptoms persist beyond a few months, they may signal cognitive decline.
Dementia, as a general term, refers to a range of progressive disorders affecting memory, thinking, and behavior, with Alzheimer's disease being the most common.