Cellular Condensates Exhibit Age-Related Electrochemical Changes, Impacting Function

Researchers have discovered that biomolecular condensates, fluid-like structures within cells, undergo electrochemical changes as they age, potentially altering their function. A study led by Yifan Dai at Washington University in St. Louis found that condensates shift from a neutral to basic pH shortly after formation, then gradually become more acidic over time, developing a core-shell structure. These changes correlate with alterations in viscosity and a decreased ability to facilitate redox reactions. The age-related electrochemical shifts also affect the condensates' interaction with amyloid-beta aggregates, influencing the formation of fibrillar networks associated with Alzheimer's disease. Scientists suggest these findings could provide insights into condensate-related diseases and potential therapeutic interventions, highlighting the importance of the solvent environment in biomolecular function. Further research is needed to determine the generality of these findings across various types of cellular condensates.