A 2025 study in Pediatric Research reveals a significant link between hypoxic burden, or oxygen deprivation during sleep, and cardiovascular issues in children with obstructive sleep apnea (OSA). The research underscores the importance of early detection and intervention to prevent long-term heart complications.
The study found that children with higher hypoxic burden showed early signs of heart dysfunction, including impaired blood vessel function, increased inflammation, and arterial remodeling. These changes can increase the lifetime risk of hypertension, atherosclerosis, and cardiac remodeling. Researchers suggest incorporating hypoxic burden assessment into routine evaluations for children with sleep-disordered breathing.
Early interventions like adenotonsillectomy, CPAP therapy, or pharmacological strategies can minimize oxygen deprivation. Longitudinal studies are recommended to monitor cardiovascular outcomes in children with OSA, focusing on reversing hypoxia-induced damage and addressing socioeconomic disparities in accessing sleep studies and specialist care.