Researchers from Oregon Health & Science University have unveiled significant findings regarding the herb Centella asiatica, known for its historical use in traditional medicine. This study, published on January 14, 2025, reveals how a water extract of the herb influences DNA methylation, a crucial epigenetic mechanism in aged mice.
The study examined the effects of Centella asiatica on male and female mice, aged approximately 60 human years, over a five-week period. Researchers identified distinct changes in DNA methylation patterns, indicating the potential of this herb to promote healthy aging.
Notably, male mice exhibited nearly ten times more differentially methylated regions compared to females, suggesting a significant gender-based difference in response to the herb. In males, hypomethylation was observed in genes linked to antioxidant pathways and mitochondrial function, which may explain the herb's cognitive-enhancing properties. In contrast, female mice displayed a dual regulation of inflammatory genes, indicating a potential role in balancing inflammatory responses.
The study also highlighted several biological pathways affected by the treatment, including oxidative stress response, energy regulation, and inflammatory balance. These findings suggest that Centella asiatica could enhance cellular health and metabolic function, making it a promising candidate for future therapeutic applications.
Importantly, the observed changes in DNA methylation were detectable in peripheral blood, pointing towards the possibility of developing blood-based biomarkers for tracking the herb's effects in clinical settings. This non-invasive approach could pave the way for further research into the herb's role in promoting brain health and longevity.
As global populations age, the implications of this research could be profound, offering new avenues for interventions aimed at mitigating age-related health issues. The study emphasizes the need for tailored therapeutic strategies, considering gender-specific responses to enhance the efficacy of Centella asiatica in promoting healthy aging.