Columbia University Identifies Neurons That Halt Eating in Mice

Researchers at Columbia University have identified specific neurons in mice that signal the body to stop eating. The study, published in *New Scientist*, found these cells, located in the brainstem, detect food-related signals and trigger the cessation of feeding. The identified neurons produce cholecystokinin, a hormone regulating appetite. Experiments showed increased activity in these neurons when mice ate, followed by a decrease. Stimulating these neurons via optogenetics caused mice to eat slower and consume less food; increased stimulation led to complete cessation of eating. Clotilde Vázquez, head of endocrinology and nutrition at the Jiménez Díaz Foundation, suggests humans likely possess similar neurons, though their function may differ. She emphasized the need for further preclinical studies before human clinical trials. Vázquez noted that while existing drugs like Ozempic target similar pathways, these new neurons could offer a more potent approach. However, she cautioned about potential rebound effects from excessive satiety. A drug activating these neurons could benefit individuals struggling to control hunger due to habit, stress, or neurotransmitter dysfunction. Clinical trials could begin within a year or two, with potential commercialization in approximately five years.