Gut Immune Cells Prevent Food Allergies, Study Finds

Researchers at the University of Washington School of Medicine have identified a unique type of immune cell that prevents the development of food allergies. The study, published in Cell, details experiments conducted on mice, focusing on RORγt+ cells found in the gut. These cells play a crucial role in building tolerance to food allergens. Investigators reported that RORγt+ cells help other components of the immune system recognize that food is not a threat. When these cells were removed from mice, the animals lost tolerance to food and began to show signs of allergic reactions. The scientists noted that similar cells exist in humans, opening potential avenues for therapies that could prevent allergic reactions, rather than just treating symptoms. This approach may also be beneficial for other gut-related conditions, including celiac disease and inflammatory bowel diseases.