Immune Cells Found to Maintain Skin Integrity, Offering Potential for New Treatments

A recent study by scientists at the National Center for Cardiovascular Research (CNIC) has identified a specialized type of immune cell that helps maintain the integrity of the skin. Published in *Nature*, the research demonstrates that neutrophils, immune cells typically known for fighting infections, also play a role in physically reinforcing the skin to prevent infections. These cells penetrate the skin to produce collagen and other proteins, strengthening the skin barrier. The findings suggest new avenues for understanding the immune system and could inspire treatments for skin diseases, inflammation, diabetes, and aging. Researchers found that neutrophils generate and remodel the skin's extracellular matrix, essential for maintaining its structure and function. The study also revealed that neutrophils actively respond to injuries by forming protective structures around wounds, preventing the entry of bacteria and toxins. A decrease in extracellular matrix formation led to more fragile and permeable skin, indicating a complex interaction between the immune system and the body's structural components.