DNA Mutations Linked to Epigenetic Changes in Aging Process, Study Finds

Researchers have discovered a connection between DNA mutations and epigenetic changes, potentially offering insights into the aging process. The study, published in "Nature Aging," analyzed data from over 9,300 cancer patients and found that mutated DNA sections exhibit less methylation, while neighboring DNA areas show hypermethylation. This suggests a biochemical domino effect where mutations affect methylation, and vice versa. Scientists developed new epigenetic clocks incorporating both genetic and epigenetic changes, indicating that mutations could influence the epigenetic clock. While the study focuses on cancer patients, further research with healthy individuals is needed to confirm these findings and understand the temporal sequence of mutations and epigenetic changes in aging.