Billionaire innovator Bryan Johnson is pursuing an unprecedented goal in human longevity through his exhaustive regimen known as Project Blueprint: reversing his biological clock by a targeted 27 years to achieve an epigenetic age of 18. This endeavor is positioned as a deep investigation into the plasticity of human biology, moving beyond typical wellness trends.
Johnson's protocol is characterized by extreme discipline and advanced monitoring. The foundation is a highly restrictive, entirely plant-based diet, calibrated to approximately 1,977 calories daily, with an emphasis on nutrient-dense foods like lentils and various berries. The framework also mandates rigorous physical activity, strict sleep hygiene, and the incorporation of cutting-edge medical interventions. These interventions include periodic plasma transfers, numerous specialized supplements, and continuous high-fidelity data collection via technologies such as MRIs and Dexa scans. Johnson has reportedly spent around $2 million annually on this self-optimization pursuit.
The intensity of this commitment yielded documented results: within a seven-month period, Johnson reported a world-record reversal of his epigenetic age by 5.1 years, dropping his multi-epi-clock average from age 47 to 42.5. Beyond this overall metric, Johnson claimed specific organs showed younger metrics, including the heart of a 37-year-old and the lung capacity of an 18-year-old. This intensive focus is aimed not just at extending lifespan but at redefining the quality of those years.
The scientific integration is paramount, yet Johnson's choices are also influenced by a unique ethical consideration: the deliberate avoidance of meat consumption due to concerns about the future ethical treatment of humanity by advanced Artificial Intelligence systems. This forward-looking perspective links personal health decisions to broader technological trajectories. The approach aligns with emerging research on cellular rejuvenation, particularly involving NAD+ precursors to support DNA repair and intermittent fasting to stimulate autophagy, the body's cellular cleanup process.
Johnson's systematic approach to cellular maintenance suggests that the body's capacity for renewal may be significantly greater than previously assumed when provided with precise environmental cues for activation. Led by physician Oliver Zolman and a team of over 30 experts, Johnson's journey functions as a real-world laboratory, demonstrating that the perceived limits of biological aging might be less a fixed destiny and more a consequence of daily choices made in service of self-restoration.
The project, which Johnson launched in 2021, is also intended to serve as a public resource, with Johnson creating The Rejuvenation Olympics to gamify the process and share protocols publicly, hoping to accelerate progress in the field of rejuvenation.